Aging is agings: towards a recursive definition of biological aging(s); part 5, Open Problems

In the last 4 posts of this study I’ve built up an argument showing the need for a definition of biological aging that consolidates existing consensus knowledge  in the field but also flexible enough to incorporate new knowledge within that current paradigm. 

This is still not the final formulation, but this is what I have right now:

‘Biological aging is agings underneath, the result of multiple, separate, diverse, interconnected, but malleable processes, eventually compromising normal functions of the organism at different rates and at all (organisational, spatiotemporal) levels.’

What are some open problems left with this definition?

I see two main problems, one is related to causality, the other related to what I call the ‘computability’ of the definition.  Continue reading “Aging is agings: towards a recursive definition of biological aging(s); part 5, Open Problems”

Aging is agings: towards a recursive definition of biological aging(s); part 4, Success criteria

In the first part of this study, Aging is agings: towards a recursive definition of biological aging(s); part 1, definition a new definition of biological aging(s) was introduced.

In the second part Aging is agings: towards a recursive definition of biological aging(s); part 2, Explication we argued why the ‘need and must’ to come up with a consensus definition and that there’s strong reasons it should be a so called explicative definition a la Carnap.

In the third part, Aging is agings: a recursive definition of biological aging(s); part 3, Recursion we explained what recursion means in the proposed definition and how it is structured further. Also we have added one modification to the proposed definitions, that is now the following:

‘Biological aging is agings underneath, the result of multiple, separate, diverse, interconnected, but malleable processes, eventually compromising normal functions of the organism at different rates and at all levels.’

Today we connect the second, explicative and third, recursive parts by going back to the 4 criteria Carnap lists for a  – good, or at least functional – scientific explicatum to meet: 

i., similarity to the explicandum, 

ii., exactness to introduce the explicatum ‘into a well-connected system of scientific concepts’,

iii., fruitfulness to be useful in formulating empirical laws or logical theorems, I take this feature roughly the same as scientific ‘utility’, ‘applicability’ or ‘productivity’,

iv., simplicity as simple as possible and allowed by the above 3 criteria.

In what follows I fill in the blanks in the separate rows of the success criteria column concerning the proposed recursive solution and will also add 2 additional criteria, that of flexibility and formal correctness. Continue reading “Aging is agings: towards a recursive definition of biological aging(s); part 4, Success criteria”

Aging is agings: a recursive definition of biological aging(s); part 3, Recursion

In the first part of this study, Aging is agings: towards a recursive definition of biological aging(s); part 1, definition the following definition of biological aging(s) was introduced:

Biological aging is agings underneath, the result of multiple, separate, diverse, interconnected, but malleable processes, eventually compromising normal functions of the organism at different rates and at all levels.

In the second part Aging is agings: towards a recursive definition of biological aging(s); part 2, Explication we argued why the ‘need and must’ to come up with a consensus definition and that there’s strong reasons it should be a so called explicative definition a la Carnap.

Today we arrive at the heart of the heart of the heart our definition, recursion. 🙂 Continue reading “Aging is agings: a recursive definition of biological aging(s); part 3, Recursion”

Aging is agings: a recursive definition of biological aging(s); part 2, Explication

In the first part of this study, Aging is agings: towards a recursive definition of biological aging(s); part 1, definition the following definition of biological aging(s) was introduced:

Biological aging is agings underneath, the result of multiple, diverse, separate but malleable processes, eventually compromising normal functions of the organism at different rates and at all levels.

Today it is explication time to build up the argument behind this definition. I have 4 points to offer today in the forms of questions and brief descriptive hints in the titles, here they are.

#1 What is the most confusing thing about biological aging? It’s diversity, plurality and broad-spectrum

#2 Why we need to come up with a good working definition of biological aging? Because current status looks like a prescientific and confusing mess

#3 Why we must come up with a good consensus definition? To acknowledge and further the emerging consensus framework within aging research

#4 What kind of definition we would like to come up with? An explicative one, both stipulative and descriptive, innovative and conservative at the same time Continue reading “Aging is agings: a recursive definition of biological aging(s); part 2, Explication”

Aging is agings: a recursive definition of biological aging(s); part 1, Definition

In the earlier post with the terrible title of What is the philosophy of biological aging research/biogerontology/translational geroscience/? Problems I listed the following as Problem #1:

What is a good working definition of biological aging, that is formally correct, scalable, yet flexible enough to incorporate new knowledge and can be used to design interventions to counteract it? 

In what follows I propose such a definition and it sounds like this:

Biological aging is agings underneath, the result of multiple, diverse, separate but malleable processes, eventually compromising normal functions of the organism at different rates and at all levels.

The definition of biological aging(s) proposed in this study

This definition of biological aging is a formally correct recursive definition, that is non-circular, consisting of a couple of bases cases serving to explain the more composite processes, being able to scale up at all levels Continue reading “Aging is agings: a recursive definition of biological aging(s); part 1, Definition”