Aging is agings: towards a recursive definition of biological aging(s); part 1, Definition

In the earlier post with the terrible title of What is the philosophy of biological aging research/biogerontology/translational geroscience/? Problems I listed the following as Problem #1:

What is a good working definition of biological aging, that is formally correct, scalable, yet flexible enough to incorporate new knowledge and can be used to design interventions to counteract it? 

In what follows I propose such a definition and it sounds like this:

Biological aging is agings underneath, the result of multiple, diverse, separate but malleable processes, eventually compromising normal functions of the organism at different rates and at all levels.

The definition of biological aging(s) proposed in this study

This definition of biological aging is a formally correct recursive definition, that is non-circular, consisting of a couple of bases cases serving to explain the more composite processes, being able to scale up at all levels Continue reading “Aging is agings: towards a recursive definition of biological aging(s); part 1, Definition”

List of criteria to qualify as a central concept/process of biological aging

In the earlier post with the terrible title of What is the philosophy of biological aging research/biogerontology/translational geroscience/? Problems I listed the following as Problem #2:

Problem #2: 2/A. What are the criteria for a biological structure/dynamics to qualify for being central in organismal level, multicellular biological aging? A corresponding question (2/B) concerning the translational aspect of geroscience might be: What quantifies/qualifies as a central biomedical structure/dynamics for being used as a medical application in counteracting human biological aging and to inform both diagnosis and treatment? A related background question: Is it possible and desirable to cut across biological pluralism concerning translational geroscience?

In my perspective paper called Cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of comprehensive organismal rejuvenation, I worked out a possible list of such criteria and provided an answer for question 2/A. Here is the corresponding, standalone excerpt from the ~30 page perspective paper.

What do we expect from a central concept, structure, process of organismal biological aging? This question is about the potential expressiveness, explanatory, predictive and modelling power of a scientific tool. We list 10 requirements, grouped according to 6 bigger concepts, highlighted in bold. Continue reading “List of criteria to qualify as a central concept/process of biological aging”

What is the philosophy of biological aging research/biogerontology/translational geroscience/? Problems

After the Introduction into the emerging field of philosophy biological aging research/biogerontology/translational geroscience I promised some actual questions, problems. I list different questions under different problems but otherwise do not differentiate questions from problems by now. 

In a way, the perspective papers, opinion pieces, review studies published in peer-reviewed literature about biological aging contain a lot, mostly implicit, formulations already that can be called philosophical problems and arguments. But time to make these more explicit and reflect to them as such.

Here is my starter list of problems and questions.

Problem #1: What is a good working definition of biological aging, that is formally correct, scalable, yet flexible enough to incorporate new knowledge and can be used to design interventions to counteract it? Continue reading “What is the philosophy of biological aging research/biogerontology/translational geroscience/? Problems”

What is the philosophy of biological aging research/biogerontology/translational geroscience/? Introduction

So far on the course of Open Lifespan the fact that my number one professional occupation is being an active aging/longevity biologist (working at an aging/longevity startup) remained quite hidden, with a reason. While Open Lifespan is an attempt to formulate ethical, political, metaphysical and psychological questions and answers around our biomedically possible, upper limit healthy longevity trajectory, the following attempt below tries to investigate the science itself, the biological and medical (together: biomedical) problems of aging and longevity. 

I would introduce here the philosophy of biological aging research /biogerontology/translational geroscience as a new, expected sub-discipline within the broadly defined field of philosophy of biology trying to frame conceptual problems and work out solutions concerning our state-of-the-art understanding of biological aging and the interventions designed to counteract it. Continue reading “What is the philosophy of biological aging research/biogerontology/translational geroscience/? Introduction”